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New Breakthrough Marijuana Terpenes Research For Pain Relief

Study reveals marijuana terpenes offer pain relief like morphine but with fewer side effects. Discover this natural alternative for effective pain management.

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Marijuana Terpenes Close Up

New Breakthrough: The Marijuana Terpenes Research For Pain Relief

Marijuana Terpenes Show Promising Pain Relief Comparable to Morphine with Fewer Side Effects, New Study Reveals.

Terpenes Show Promise for Pain Relief

A recent federally funded study has unveiled that cannabis terpenes might serve as effective treatments for chronic neuropathic pain. The research demonstrated that an injected dose of these compounds led to a reduction in pain markers comparable to a lower dose of morphine. Furthermore, terpenes appeared to enhance morphine’s effectiveness when used together.

No Addiction Risk with Terpenes

Significantly, none of the terpenes tested produced a rewarding response similar to morphine. This finding indicates that terpenes could be potent pain relievers without the risk of addiction or unpleasant side effects. However, the study found that terpenes administered via vaporization or orally had minimal impact on pain.

Study Details and Key Findings

Published in the journal PAIN by the International Association for the Study of Pain, the study titled “Terpenes from Cannabis sativa induce antinociception in a mouse model of chronic neuropathic pain via activation of adenosine A2A receptors,” involved researchers from the University of Arizona’s Comprehensive Center for Pain and Addiction and the National Institutes of Health (NIH).

Lead researcher John Streicher, a pharmacology professor at the University of Arizona’s College of Medicine, emphasized the potential of terpenes in managing chronic pain. He noted, “Terpenes are highly effective at relieving a specific type of chronic pain with minimal and manageable side effects.”

Marijuana Terpenes

Marijuana Terpenes

Comparing Terpenes with THC and CBD

While compounds like THC and CBD in marijuana have shown moderate efficacy in pain management, they often come with unwanted psychoactive effects. This limitation has shifted attention to other potentially therapeutic components of cannabis, such as minor cannabinoids, flavonoids, and terpenes.

Unique Terpene Diversity in Cannabis

The study highlighted that cannabis is unique in its terpene diversity, with up to 150 different terpenes. Most plants have only a couple of dominant terpene species. The research specifically examined five terpenes—alpha-humulene, beta-caryophyllene, beta-pinene, geraniol, and linalool—found in moderate to high levels within cannabis.

Testing Terpenes in Mice

Mice were injected with terpene solutions to evaluate their effects on peripheral neuropathic and inflammatory pain. These pains were induced through chemotherapy drugs and hind paw injections, respectively. Terpenes were also administered orally and through vaporization.

Each terpene was tested individually against a morphine control to assess efficacy. The results showed that all terpenes reduced markers of neuropathic pain. All except beta-pinene were effective against inflammatory pain. Notably, combining terpenes with lower doses of morphine produced an enhanced pain-relieving effect.

Potential for Combination Therapy

This finding suggests the potential for combination therapy with opioids and terpenes to improve pain relief while reducing opioid addiction risks. Streicher explained, “A combination therapy of an opioid with a high level of terpene could enhance pain relief and block opioid addiction potential.”

Reward and Dysphoric Effects

Importantly, geraniol and linalool did not show preference or aversion in reward conditioning tests, suggesting no reward or dysphoric side effects. In contrast, alpha-humulene and beta-caryophyllene showed aversive responses, indicating potential dysphoric effects under certain conditions.

Bioavailability Challenges

The study noted that injected terpenes were effective, but oral and vaporized terpenes had limited impact due to low bioavailability. This finding contrasts with anecdotal reports of terpene effects when inhaled or taken orally, possibly influenced by the pleasant aroma leading to a placebo effect.

Mechanistic Insights and Future Research

On a mechanistic level, terpenes may play an anti-inflammatory role and interact directly with certain nervous system receptors. The study suggested terpenes might act as A2AR agonists, potentially engaging different pain sites selectively.

The research underscores the need for further study to address translational challenges like bioavailability and tolerance. The authors proposed exploring the mechanisms of these terpenes further to develop them into new clinical therapies.

Broader Implications and Future Directions

Building on previous research where terpenes mimicked cannabinoid effects in reducing acute pain in animal models, the study highlights the growing interest in minor cannabis components. Recent studies have explored the synergy between cannabinoids and terpenes, known as the entourage effect, emphasizing the importance of considering the whole plant for medicinal use.

Other studies have shown the potential of various cannabis compounds to enhance therapeutic benefits, reduce side effects, and improve overall health outcomes. These findings indicate a broader therapeutic potential for cannabis beyond primary cannabinoids like THC and CBD.

In conclusion, the promising results of this study point to the need for further research into the therapeutic potential of cannabis terpenes. The potential for pain relief without the risk of addiction or severe side effects makes terpenes an exciting area of study in pain management.

Medical Cannabis

Night Sweats? It Might Actually Be The Joint Fundamentals

Discover the surprising link between night sweating and marijuana use. Get insights to improve your health. Click now for details!

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Night Sweat

Night Sweats? It Might Actually Be The Joint Fundamentals

Sweating during sleeping

Sweating during sleeping

Introduction

With ongoing legalization and decriminalization in many regions, marijuana, also known as cannabis, has become one of the most commonly used recreational drugs globally today. This has significantly increased public interest in its effects, both positive and negative. Among the less discussed side effects is the occurrence of night sweats, which can significantly affect the quality of sleep and overall health. This article delves into the correlation between smoking marijuana and night sweats, exploring potential causes and implications.

Understanding Night Sweats

Night sweats, or nocturnal hyperhidrosis, refer to excessive sweating during sleep that can soak through clothing and bedding. They can be caused by various factors, including infections, hormonal imbalances, medication side effects, and underlying medical conditions. Understanding the potential link between marijuana use and night sweats requires an examination of how marijuana interacts with the body’s systems.

The Physiology of Marijuana

Marijuana contains several active compounds, the most notable being delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is the psychoactive component responsible for the “high” sensation, while CBD is known for its non-psychoactive therapeutic effects. These compounds interact with the endocannabinoid system (ECS) in the human body, which plays a crucial role in regulating various physiological processes, including temperature regulation and sweating.

Potential Mechanisms Linking Marijuana to Night Sweats

1. Thermoregulatory Effects: THC can influence the hypothalamus, the part of the brain responsible for maintaining body temperature. By altering the hypothalamic activity, THC may cause fluctuations in body temperature, leading to episodes of excessive sweating during the night.

2. Anxiety and Stress: Marijuana can affect mood and anxiety levels. For some users, especially those prone to anxiety or using high-THC strains, marijuana can exacerbate stress and anxiety. Increased anxiety can lead to night sweats, as the body’s fight-or-flight response triggers sweating as a stress response.

3. Withdrawal Symptoms: Regular marijuana users who abruptly stop or reduce their intake may experience withdrawal symptoms, including night sweats. This is due to the body’s readjustment to the absence of cannabinoids that it had become accustomed to.

4. Hormonal Fluctuations: Marijuana use can influence hormonal balance, including cortisol levels, which play a role in the body’s stress response. Changes in cortisol levels can affect sweating patterns.

It Might Be The Joint You Smoked

It Might Be The Joint You Smoked

Research Findings

Limited but growing studies indicate a direct correlation between marijuana use and night sweats. While anecdotal reports and clinical observations suggest a link, establishing a clear causal relationship requires more comprehensive, controlled studies. A study published in the Journal of Clinical Sleep Medicine highlighted that cannabis use could impact sleep architecture and the prevalence of sleep disturbances, including night sweats.

Managing Night Sweats for Marijuana Users

For individuals experiencing night sweats related to marijuana use, several strategies can help manage the condition:

1. Adjust Dosage and Strains: Experimenting with different strains, particularly those with lower THC levels and higher CBD content, may reduce night sweats.

2. Hydration and Environment: Staying hydrated and maintaining a cool sleeping environment can help mitigate the severity of night sweats.

3. Consistent Usage Patterns: Avoiding abrupt cessation and instead gradually reducing intake can help prevent withdrawal-related night sweats.

“Consulting healthcare providers can benefit you. Seek medical advice to rule out underlying causes and get personalized recommendations.”

Conclusion

While we do not fully understand the correlation between smoking marijuana and night sweats, evidence suggests a potential link through various physiological mechanisms. As marijuana use becomes more widespread, understanding its side effects, including night sweats, is crucial for informed and responsible consumption. Further research is needed to clarify this relationship and develop effective strategies for managing any adverse effects.

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