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Pharma’s Compromise: Keeping You Out From Real Healing

Unlock true healing potentials! Discover how Pharma’s compromises may keep you from real wellness. Explore now for genuine solutions and reclaim your health.

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Bad Pills

Pharma: They never really want you to feel better.

Pills

Pills

The statement “pharma – they never want you to feel better” is a common sentiment expressed by some individuals critical of the pharmaceutical industry. It reflects a perception that pharmaceutical companies prioritize profit over patient well-being and may not always have patients’ best interests at heart. Here’s an exploration of the sentiment:

 

 

  1. Profit Motive:

Critics argue that pharmaceutical companies are primarily driven by profit, leading them to prioritize the development and marketing of drugs that are profitable rather than those that are most effective or beneficial for patients. This profit-driven approach can sometimes result in the prioritization of treatments for chronic conditions over cures, as ongoing treatment provides a continuous revenue stream.

  1. Drug Pricing:

The high cost of many prescription medications is a source of frustration for patients and contributes to the perception that pharmaceutical companies prioritize profits over affordability and accessibility. Drug pricing practices, such as price hikes for essential medications and the lack of transparency in pricing decisions, have fueled public outrage and skepticism.

  1. Marketing and Promotion:

Pharmaceutical companies invest heavily in marketing and promotion to physicians and consumers, often using tactics that critics argue are misleading or manipulative. Direct-to-consumer advertising, for example, has been criticized for promoting unnecessary or potentially harmful medications to patients.

  1. Regulatory Capture:

Some critics believe that pharmaceutical companies have undue influence over regulatory agencies and policymakers, which can compromise the integrity of the drug approval process and result in the approval of drugs with questionable efficacy or safety profiles. This phenomenon, known as regulatory capture, raises concerns about conflicts of interest and the ability of regulatory agencies to adequately protect public health.

  1. Alternative Therapies:

The rise of alternative and complementary therapies, including medical cannabis, has led some individuals to seek alternatives to traditional pharmaceutical treatments. These therapies are often perceived as more natural and holistic, with fewer side effects and a focus on treating the root cause of illness rather than just managing symptoms.

While these criticisms highlight valid concerns about the pharmaceutical industry, it’s important to recognize that pharmaceutical companies have also made significant contributions to medical science and public health through the development of life-saving medications and treatments. Ultimately, the choice between pharmaceutical drugs and alternative therapies depends on individual circumstances, preferences, and medical needs.

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Medical Cannabis

New Breakthrough Marijuana Terpenes Research For Pain Relief

Study reveals marijuana terpenes offer pain relief like morphine but with fewer side effects. Discover this natural alternative for effective pain management.

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Marijuana Terpenes Close Up

New Breakthrough: The Marijuana Terpenes Research For Pain Relief

Marijuana Terpenes Show Promising Pain Relief Comparable to Morphine with Fewer Side Effects, New Study Reveals.

Terpenes Show Promise for Pain Relief

A recent federally funded study has unveiled that cannabis terpenes might serve as effective treatments for chronic neuropathic pain. The research demonstrated that an injected dose of these compounds led to a reduction in pain markers comparable to a lower dose of morphine. Furthermore, terpenes appeared to enhance morphine’s effectiveness when used together.

No Addiction Risk with Terpenes

Significantly, none of the terpenes tested produced a rewarding response similar to morphine. This finding indicates that terpenes could be potent pain relievers without the risk of addiction or unpleasant side effects. However, the study found that terpenes administered via vaporization or orally had minimal impact on pain.

Study Details and Key Findings

Published in the journal PAIN by the International Association for the Study of Pain, the study titled “Terpenes from Cannabis sativa induce antinociception in a mouse model of chronic neuropathic pain via activation of adenosine A2A receptors,” involved researchers from the University of Arizona’s Comprehensive Center for Pain and Addiction and the National Institutes of Health (NIH).

Lead researcher John Streicher, a pharmacology professor at the University of Arizona’s College of Medicine, emphasized the potential of terpenes in managing chronic pain. He noted, “Terpenes are highly effective at relieving a specific type of chronic pain with minimal and manageable side effects.”

Marijuana Terpenes

Marijuana Terpenes

Comparing Terpenes with THC and CBD

While compounds like THC and CBD in marijuana have shown moderate efficacy in pain management, they often come with unwanted psychoactive effects. This limitation has shifted attention to other potentially therapeutic components of cannabis, such as minor cannabinoids, flavonoids, and terpenes.

Unique Terpene Diversity in Cannabis

The study highlighted that cannabis is unique in its terpene diversity, with up to 150 different terpenes. Most plants have only a couple of dominant terpene species. The research specifically examined five terpenes—alpha-humulene, beta-caryophyllene, beta-pinene, geraniol, and linalool—found in moderate to high levels within cannabis.

Testing Terpenes in Mice

Mice were injected with terpene solutions to evaluate their effects on peripheral neuropathic and inflammatory pain. These pains were induced through chemotherapy drugs and hind paw injections, respectively. Terpenes were also administered orally and through vaporization.

Each terpene was tested individually against a morphine control to assess efficacy. The results showed that all terpenes reduced markers of neuropathic pain. All except beta-pinene were effective against inflammatory pain. Notably, combining terpenes with lower doses of morphine produced an enhanced pain-relieving effect.

Potential for Combination Therapy

This finding suggests the potential for combination therapy with opioids and terpenes to improve pain relief while reducing opioid addiction risks. Streicher explained, “A combination therapy of an opioid with a high level of terpene could enhance pain relief and block opioid addiction potential.”

Reward and Dysphoric Effects

Importantly, geraniol and linalool did not show preference or aversion in reward conditioning tests, suggesting no reward or dysphoric side effects. In contrast, alpha-humulene and beta-caryophyllene showed aversive responses, indicating potential dysphoric effects under certain conditions.

Bioavailability Challenges

The study noted that injected terpenes were effective, but oral and vaporized terpenes had limited impact due to low bioavailability. This finding contrasts with anecdotal reports of terpene effects when inhaled or taken orally, possibly influenced by the pleasant aroma leading to a placebo effect.

Mechanistic Insights and Future Research

On a mechanistic level, terpenes may play an anti-inflammatory role and interact directly with certain nervous system receptors. The study suggested terpenes might act as A2AR agonists, potentially engaging different pain sites selectively.

The research underscores the need for further study to address translational challenges like bioavailability and tolerance. The authors proposed exploring the mechanisms of these terpenes further to develop them into new clinical therapies.

Broader Implications and Future Directions

Building on previous research where terpenes mimicked cannabinoid effects in reducing acute pain in animal models, the study highlights the growing interest in minor cannabis components. Recent studies have explored the synergy between cannabinoids and terpenes, known as the entourage effect, emphasizing the importance of considering the whole plant for medicinal use.

Other studies have shown the potential of various cannabis compounds to enhance therapeutic benefits, reduce side effects, and improve overall health outcomes. These findings indicate a broader therapeutic potential for cannabis beyond primary cannabinoids like THC and CBD.

In conclusion, the promising results of this study point to the need for further research into the therapeutic potential of cannabis terpenes. The potential for pain relief without the risk of addiction or severe side effects makes terpenes an exciting area of study in pain management.

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